University of Hawaii Pediatric Residency Program
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Marian Melish MD

Speciality: Infectious Diseases

Location (Faculty):
Department of Pediatrics - Kapi`olani Medical Center for Women & Children 1319 Punahou Street, Honolulu, Hawaii 96826
Marian Melish, MD is Professor of Pediatrics, Tropical Medicine and Medical Microbiology.  She is board-certified in Pediatrics, Pediatric Emergency Medicine and Pediatric Infectious Disease.  She assumed the post of Infectious Disease Division Chief in July 2002.  Her major administrative role is Medical Director of Infection Control at Kapiolani Medical Center for Women and Children. On a department level she co-chairs the Resident Recruitment effort. Her major research effort in Kawasaki Disease (KD) is studying the pathogenesis of the inflammatory vasculitis and its immunologic basis. She participates in the international studies of the genome in KD patients and their parents. Another ongoing project is the study of the incidence of Kawasaki Disease related to climate factors.  Together with Dr. Venu Reddy of the Cardiology Division and 2 pediatric residents, Drs. Andras Bratincsak and Dr. Purohit Prashant she designed and carried out a study of echocardiographic appearance of the coronary arteries in KD comparing their vessel diameter to that of febrile children with other illnesses. This study demonstrated that fever alone does not dilate the coronary arteries thus demonstrating that coronary dilation can be used as a diagnostic and prognostic marker in early KD. Using this insight, Dr. Melish and Bratincsak have been awarded research grants from the federal NIH, COBRE, and CTR-IN sources in 2015-6 to study the molecular events in cardiovascular remodeling in Kawasaki Disease, Dr. Melish and Bratincsak have begun a placebo controlled clinical trial studying the effect of Doxycycline on developing coronary artery abnormalities in Kawasaki Disease.  Dr. Melish’s other research interest is in staphylococcal infections and staphylococcal toxins.  She was the senior author of a seminal study demonstrating that a program of daily application of Muprocin ointment to the nares and umbilicus of NICU infants acts as a barrier to staphylococcal colonization and reduces the risk of severe invasive nosocomial staphylococcal infections.  She continues to study nosocomial infections in the NICU, meeting regularly with NICU leadership and carrying out performance improvement projects.  She was the founding chair of the International Kawasaki Disease Symposia which are held every 4 years and will be the co-President of the 12th international symposium to be held in Japan in 2019.  Dr. Melish and Dr. Ching published a paper this year describing the clinical and imaging features of the first infant born in the US with the Congenital Zika Virus Syndrome.  This is a new focus of research for our division, We are now following the progress of 6 infants with congenital exposure to Zika virus, 2 of whom have severe neurologic abnormalities.

She is a world-renowned infectious disease specialist and was selected by a national publication as one of the top 100 physicians in the USA. She is a fellow of the American Academy of Pediatrics (AAP). She is a graduate of Middlebury College in Vermont, where she majored in English and Chemistry. She graduated from Yale Medical School and did her pediatric residency in infectious disease at the University of Rochester, in Rocherster New York. She has numerous publications in peer reviewed journals and textbooks. She has lectured at many national meetings and has been a visiting professor at other pediatrics programs. She is the Division Chief of Pediatric Infectious Disease in the Department of Pediatrics. While her academic, research and teaching accomplishments are mostly to the field of pediatric infectious disease, she is also board certified in pediatrics and pediatric emergency medicine. She is closely involved in the residency selection and recruitment process for the Department of Pediatrics. She is regarded as a highly knowledgeable clinician and an excellent teacher of residents and medical students. The Division of Pediatric Emergency Medicine is fortunate to have a physician of such high regard amongst our group. For KMCWC, she is the chairman of the Infection Control Committee.

Research interests: Kawasaki disease, Staphylococcal infections.

Recent Publication:
Culjat M, Darling SE, Nerurkar VR, Ching N, Kumar M, Min SK, Wong R, Grant L, and Melish ME. Clinical and Imaging Findings in an Infant with Zika Embryopathy. Clin Infect Dis. (2016) doi: 10.1093/cid/ciw324 First published online: May 18, 2016.
Book Chapter:

Melish  M. History of Kawasaki Disease in Kawasaki Disease Saji, BT, Newberger, JW, Burns, JC, Takahashi, T editors, Springer 2016.

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